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Mrs E (December 1962–October 2015), is the main antagonist of iMovie's superhero drama The Flash: The Marvellous Chemistary. Mrs E is a primary assistant educating in Arvalee School and Resource Centre as a 'serious villain' which cause Barry and Sheldon tangling together. In October 2015, Barry and Sheldon went running to Drumragh River, but so does Mrs E and Sheldon punches and she falls by her death to the river of Halloween murder. Played by Yvonne Entwistle: Top 100 Comic Book Villains of All Time, as she debuted in Flash v.1 #106.